池ノ上 学 (イケノウエ サトル)

Ikenoue, Satoru

写真a

所属(所属キャンパス)

医学部 産婦人科学教室 (信濃町)

職名

助教(有期)

 

研究キーワード 【 表示 / 非表示

  • Developmental Origins of Health and Disease

  • Fetal body composition

  • 胎児生理学

  • 胎児超音波

研究テーマ 【 表示 / 非表示

  • Fetal body composition, 

    2014年04月
    -
    継続中

     研究概要を見る

    超音波を用いた胎児身体組成の評価

  • 胎児肝血流量, 

    2014年04月
    -
    継続中

     研究概要を見る

    胎児肝血流量と胎児身体組成との関連についての検討

共同研究希望テーマ 【 表示 / 非表示

  • 子宮内環境(胎児発育不全)と小児肥満の関連

    産学連携、民間を含む他機関等との共同研究等を希望する,  希望形態: 受託研究, 共同研究

 

論文 【 表示 / 非表示

  • Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus

    Kasuga Yoshifumi, Miyakoshi Kei, Tajima Atsushi, Saisho Yoshifumi, Ikenoue Satoru, Ochiai Daigo, Matsumoto Tadashi, Arata Naoko, Hata Kenichiro, Tanaka Mamoru

    Journal of Diabetes Investigation 2018年01月

    ISSN  2040-1116

     概要を見る

    <p>Aims/Introduction: Risk factors of type 2 diabetes mellitus in Japanese women with recent gestational diabetes mellitus are unknown. The objective of the present study was to investigate the clinical and genetic characteristics associated with postpartum abnormal glucose tolerance in Japanese women with gestational diabetes mellitus. Materials and Methods: A total of 213 Japanese women with recent gestational diabetes mellitus who underwent a postpartum 2-h oral glucose tolerance test were investigated. The association between antepartum clinical characteristics and postpartum abnormal glucose tolerance (diabetes or prediabetes based on the Japan Diabetes Society criteria) was examined. Frequencies of 45 known type 2 diabetes mellitus-associated genetic variants were also compared between women with and without postpartum abnormal glucose tolerance. Results: A total of 59 women showed postpartum abnormal glucose tolerance (prediabetes, n = 51; diabetes, n = 8). Plasma glucose levels at 1 or 2 h, the insulinogenic index and the insulin secretion-sensitivity index-2 of the antepartum oral glucose tolerance test were independent of postpartum abnormal glucose tolerance risk factors (P = 0.006, P = 0.00002, P = 0.01 and P = 0.006, respectively). Four genetic variants (rs266729 [ADIPOQ], rs6017317 [HNF4A], rs5215 [KCNJ11] and rs7177055 [HMG20A]) showed a nominally significant association with postpartum abnormal glucose tolerance (P &lt; 0.05, respectively). Among these, three were related to insulin secretion. Postpartum abnormal glucose tolerance risk significantly increased with increasing risk-allele number (P = 0.0005; odds ratio 1.91). Conclusions: Clinical features and genetic variants related to impaired insulin secretion are risk factors of postpartum abnormal glucose tolerance in Japanese women with recent gestational diabetes mellitus.</p>

  • Cover Image, Volume 176A, Number 1, January 2018

    Ikenoue S., Miyakoshi K., Ishii T., Sato Y., Otani T., Akiba Y., Kasuga Y., Ochiai D., Matsumoto T., Ichihashi Y., Matsuzaki Y., Tachikawa K., Michigami T., Nishimura G., Ikeda K., Hasegawa T., Tanaka M.

    American journal of medical genetics. Part A (American journal of medical genetics. Part A)  176 ( 1 ) i 2018年01月

    ISSN  1552-4825

     概要を見る

    © 2017 Wiley Periodicals, Inc. The cover image, by Satoru Ikenoue et al., is based on the Clinical Report Discordant fetal phenotype of hypophosphatasia in two siblings, DOI: 10.1002/ajmg.a.38531.

  • Discordant fetal phenotype of hypophosphatasia in two siblings

    Ikenoue S., Miyakoshi K., Ishii T., Sato Y., Otani T., Akiba Y., Kasuga Y., Ochiai D., Matsumoto T., Ichihashi Y., Matsuzaki Y., Tachikawa K., Michigami T., Nishimura G., Ikeda K., Hasegawa T., Tanaka M.

    American Journal of Medical Genetics, Part A (American Journal of Medical Genetics, Part A)  176 ( 1 ) 171 - 174 2018年01月

    ISSN  1552-4825

     概要を見る

    © 2017 Wiley Periodicals, Inc. Hypophosphatasia (HPP) is an autosomal recessive metabolic disorder with impaired bone mineralization due to mutations in the ALPL gene. The genotype-phenotype correlation of this disorder has been widely described. Here, we present two affected siblings, whose fetal phenotypes were discordant. A 31-year-old Japanese woman, G0P0, was referred to our institution because of fetal micromelia. After obstetric counseling, the pregnancy was terminated at 21 weeks’ gestation. Post-mortem radiographs demonstrated severely defective mineralization of the skeleton. The calvarial, spinal, and tubular bones were mostly missing. Only the occipital bones, mandible, clavicles, ribs, one thoracic vertebra, ilia, and tibia were relatively well ossified. The radiological findings suggested lethal HPP. Genetic testing for genomic DNA extracted from the umbilical cord identified compound heterozygous mutations in the ALPL gene (c.532T>C, p.Y178H; c.1559delT, p.Leu520Argfs*86). c.532T>C was a novel variant showing no residual activity of the protein by the functional analysis. The parents were heterozygous carriers. In the next pregnancy, biometric values on fetal ultrasonography at 20 and 26 weeks’ gestation were normal. At 34 weeks, however, a small chest and shortening of distal long bones came to attention. The neonate delivered at 41 weeks showed serum ALP of <5U/L. Radiological examination showed only mild thoracic hypoplasia and metaphyseal mineralization defects of the long bones. ALP replacement therapy was introduced shortly after birth, and the neonate was discharged at day 22 without respiratory distress. Awareness of discordant fetal phenotypes in siblings with HPP precludes a diagnostic error, and enables early medical intervention to mildly affected neonates.

  • Association between supraclavicular brown adipose tissue composition at birth and adiposity gain from birth to 6 months of age

    Entringer Sonja, Rasmussen Jerod, Cooper Dan M., Ikenoue Satoru, Waffarn Feizal, Wadhwa Pathik D., Buss Claudia

    Pediatric Research 82 ( 6 ) 1017 - 1021 2017年12月

    ISSN  0031-3998

     概要を見る

    <p>BackgroundBrown adipose tissue (BAT) is associated with higher energy expenditure and lower adiposity in adults. However, the relationship between BAT composition and adiposity in early life is unknown. The objective of this study was to test the hypothesis that brown fat composition at birth is prospectively associated with adiposity gain during the first 6 months of postnatal life.MethodsN=35 healthy infants were followed up prospectively from intrauterine life and birth through 6 months of age. Dixon magnetic resonance imaging (MRI) scans were conducted during the neonatal period to characterize supraclavicular BAT composition. Dual-energy X-ray absorptiometry to assess total body composition was performed within the first and sixth months of life.ResultsAfter adjusting for potential confounding factors, a more brown-like composition (smaller fat fraction) of the supraclavicular BAT depot was associated with a smaller increase in percent body fat over the first 6 months of postnatal life.ConclusionsA more brown-like BAT composition at birth appears to be protective against excess adiposity gain in early life. Newborn BAT tissue may constitute a target for prevention strategies against the subsequent development of obesity.</p>

  • Association of ultrasound-based measures of fetal body composition with newborn adiposity

    Ikenoue S., Waffarn F., Sumiyoshi K., Ohashi M., Ikenoue C., Buss C., Gillen D. L., Simhan H. N., Entringer S., Wadhwa P. D.

    Pediatric obesity 12   86 - 93 2017年08月

    ISSN  2047-6302

     概要を見る

    <p>Background: Newborns exhibit substantial variation in gestational age-adjusted and sex-adjusted fat mass proportion. The antecedent characteristics of fetal body composition that are associated with newborn fat mass proportion are poorly understood. Objective: The aim of this study was to determine whether a composite measure of fetal fat mass is prospectively associated with newborn adiposity. Methods: In a longitudinal study of 109 low-risk pregnancies, fetal ultrasonography was performed at approximately 12, 20 and 30 weeks gestation. Estimated fetal adiposity (EFA) was derived by integrating cross-sectional arm and thigh per cent fat area and anterior abdominal wall thickness. Newborn per cent body fat was quantified by Dual Energy X-Ray Absorptiometry. The association between EFA and newborn per cent body fat was determined by multiple linear regression. Results: After controlling for confounding factors, EFA at 30 weeks was significantly associated with newborn per cent body fat (standardized β = 0.41, p &lt; 0.001) and explained 24.0% of its variance, which was substantially higher than that explained by estimated fetal weight (8.1%). The observed effect was driven primarily by arm per cent fat area. Conclusions: A composite measure of fetal adiposity at 30 weeks gestation may constitute a better predictor of newborn per cent body fat than estimated fetal weight by conventional fetal biometry. Fetal arm fat deposition may represent an early indicator of newborn adiposity. After replication, these findings may provide a basis for an improved understanding of the ontogeny of fetal fat deposition, thereby contributing to a better understanding of its intrauterine determinants and the development of potential interventions.</p>

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研究発表 【 表示 / 非表示

  • Maternal Insulin Resistance Affects Fetal Body Composition.

    池ノ上 学

    REPRODUCTIVE SCIENCES, 2018年03月, ポスター(一般)

  • Prospective association of fetal liver blood flow at 30 weeks gestation with newborn adiposity

    池ノ上 学

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2017年01月, ポスター(一般)

 

担当授業科目 【 表示 / 非表示

  • 産科学講義

    2019年度