池ノ上 学 (イケノウエ サトル)

Ikenoue, Satoru

写真a

所属(所属キャンパス)

医学部 産婦人科学教室 周産期学 (信濃町)

職名

助教(有期)

 

研究キーワード 【 表示 / 非表示

  • Developmental Origins of Health and Disease

  • Fetal body composition

  • 胎児生理学

  • 胎児超音波

研究テーマ 【 表示 / 非表示

  • 胎児肝血流量, 

    2014年04月
    -
    継続中

     研究概要を見る

    胎児肝血流量と胎児身体組成との関連についての検討

  • Fetal body composition, 

    2014年04月
    -
    継続中

     研究概要を見る

    超音波を用いた胎児身体組成の評価

共同研究希望テーマ 【 表示 / 非表示

  • 子宮内環境(胎児発育不全)と小児肥満の関連

    産学連携、民間を含む他機関等との共同研究等を希望する,  希望形態: 受託研究, 共同研究

 

論文 【 表示 / 非表示

  • In Utero Amniotic Fluid Stem Cell Therapy Protects Against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion

    Abe, Y., Ochiai, D., Masuda, H., Sato, Y., Otani, T., Fukutake, M., Ikenoue, S., Miyakoshi, K., Okano, H. and Tanaka, M.

    Stem Cells Transl Med 2019年08月

    ISSN  2157-6564

     概要を見る

    Despite the poor prognosis associated with myelomeningocele (MMC), the options for prenatal treatments are still limited. Recently, fetal cellular therapy has become a new option for treating birth defects, although the therapeutic effects and mechanisms associated with such treatments remain unclear. The use of human amniotic fluid stem cells (hAFSCs) is ideal with respect to immunoreactivity and cell propagation. The prenatal diagnosis of MMC during early stages of pregnancy could allow for the ex vivo proliferation and modulation of autologous hAFSCs for use in utero stem cell therapy. Therefore, we investigated the therapeutic effects and mechanisms of hAFSCs-based treatment for fetal MMC. hAFSCs were isolated as CD117-positive cells from the amniotic fluid of 15- to 17-week pregnant women who underwent amniocentesis for prenatal diagnosis and consented to this study. Rat dams were exposed to retinoic acid to induce fetal MMC and were subsequently injected with hAFSCs in each amniotic cavity. We measured the exposed area of the spinal cord and hepatocyte growth factor (HGF) levels at the lesion. The exposed spinal area of the hAFSC-treated group was significantly smaller than that of the control group. Immunohistochemical analysis demonstrated a reduction in neuronal damage such as neurodegeneration and astrogliosis in the hAFSC-treated group. Additionally, in lesions of the hAFSC-treated group, HGF expression was upregulated and HGF-positive hAFSCs were identified, suggesting that these cells migrated to the lesion and secreted HGF to suppress neuronal damage and induce neurogenesis. Therefore, in utero hAFSC therapy could become a novel strategy for fetal MMC. Stem Cells Translational Medicine 2019.

  • Changes in bone metabolic profile associated with pregnancy or lactation

    Miyamoto, T., Miyakoshi, K., Sato, Y., Kasuga, Y., Ikenoue, S., Miyamoto, K., Nishiwaki, Y., Tanaka, M., Nakamura, M. and Matsumoto, M.

    Sci Rep 9 ( 1 ) 6787 2019年05月

    ISSN  2045-2322

     概要を見る

    Calcium and nutrients are transferred from mothers to fetuses or infants during pregnancy or lactation, respectively, promoting metabolic changes in the mother, many uncharacterized. To evaluate these changes, we undertook two parallel studies. In one we analyzed fourteen clinical cases of vertebral fragility fractures, at or before three months after partum, in mothers who breastfed their infants. In the other, we enrolled 79 additional pregnant subjects, some who chose to breastfeed and others who did not, and analyzed changes in bone metabolic status starting between 34 and 36 weeks of gestation and ending one month after partum. In the larger group, bone-resorbing and bone-forming parameters such as serum TRACP5b and osteocalcin, respectively, significantly increased after partum. Among parameters that changed after partum, serum PTH and the bone-resorbing markers serum TRACP5b and urine NTX were significantly higher in mothers who only breastfed infants compared to mothers who fed infants formula or a mix of both. However, bone-forming parameters were comparable between breastfeeding and non-breast-feeding groups after partum, suggesting that elevated bone-resorption occurs only in the breastfeeding group. Radiographic analysis after partum demonstrated that no subject among the 79 analyzed showed vertebral fractures, even those who breastfed exclusively. Among fracture cases analyzed, subjects exhibited significantly lower bone mineral density than did non-fracture cases in breastfeeding-only subjects. We conclude that bone metabolic status significantly changes over the period between pregnancy and post-partum lactation, and that low bone mineral density seen in a small subset of breastfeeding-only cases likely causes post-partum vertebral fragility fractures.

  • Glycemic and metabolic features in gestational diabetes: singleton versus twin pregnancies

    Akiba, Y., Miyakoshi, K., Ikenoue, S., Saisho, Y., Kasuga, Y., Ochiai, D., Matsumoto, T. and Tanaka, M.

    Endocr J 2019年04月

    ISSN  1348-4540

     概要を見る

    A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin Secretion-Sensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60% vs. 71%). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0% vs. 5.2%, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45% vs. 32% and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.

  • Maternal Daily Intake of Polyphenol-Rich Dark Chocolate and Premature Closure of Ductus Arteriosus

    Anko, Mayuka, Ikenoue, Satoru, Kawamura, Makoto and Yakubo, Kazumi

    Biomed J Sci & Tech Res 21 ( 2 )  2019年

  • Impaired fetal growth in mothers with inadequate gestational weight gain: a retrospective study in Japanese uncomplicated pregnancy

    Ikenoue, S., Miyakoshi, K., Kasuga, Y., Ochiai, D., Matsumoto, T. and Tanaka, M.

    J Matern Fetal Neonatal Med    1 - 5 2018年12月

    ISSN  1476-4954

     概要を見る

    INTRODUCTION: The average birth weight in Japan has gradually decreased and the number of low birth weight infant has increased over the last 30 years. Japanese pregnant women are characterized with lower prevalence of obesity than those in other developed countries, and maternal underweight before pregnancy is independently associated with low birth weight. However, the association between maternal inadequate gestational weight gain (GWG) and the risk of small for gestational age (SGA) in Japanese uncomplicated pregnant women has not been fully understood. This study aimed to examine the effect of maternal inadequate GWG on the risk of SGA in Japanese uncomplicated pregnancies. METHODS: We retrospectively analyzed uncomplicated Japanese singleton pregnancies that delivered at term gestation in our institution from 2006 to 2016. The association between GWG and birth weight was analyzed by multiple linear regression. Potential confounding factors included maternal age, parity, prepregnancy BMI, and neonatal sex. The association between inadequate GWG and SGA was also examined by logistic regression. RESULTS: A total of 3837 mother-neonate dyads were analyzed. Maternal GWG was 10.1 +/- 3.7 kg (mean +/- SD), and 2529 (66%) had inadequate GWG. After adjusting for confounding factors, GWG significantly correlated with birth weight (standardized beta = 0.199, p < .001). Inadequate GWG increased the risk of delivering SGA neonate (adjusted odds ratio (aOR) = 1.97 [1.45-2.68], p < .001). This association was particularly pronounced in underweight (aOR = 2.95 [1.38-6.29], p = .005) and normal weight mothers (aOR = 1.79 [1.27-2.52], p = .001), and not in overweight/obese mothers (p = .115). CONCLUSION: Maternal GWG is associated with birth weight in Japanese women with uncomplicated singleton pregnancies. Inadequate GWG is an important risk factor of SGA, particularly in non-obese women. The present finding would potentially provide further evidence that promoting adequate gestational weight gain in Japanese underweight and normal weight mothers would reduce SGA, as well as metabolic dysfunction in later life.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • Maternal Insulin Resistance Affects Fetal Body Composition.

    池ノ上 学

    REPRODUCTIVE SCIENCES, 2018年03月, ポスター(一般)

  • Prospective association of fetal liver blood flow at 30 weeks gestation with newborn adiposity

    池ノ上 学

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2017年01月, ポスター(一般)

 

担当授業科目 【 表示 / 非表示

  • 産科学講義

    2019年度