岡本 一真 (オカモト カズマ)

Okamoto, Kazuma

写真a

所属(所属キャンパス)

医学部 外科学教室(心臓血管) (信濃町)

職名

講師

メールアドレス

メールアドレス

HP

外部リンク

学歴 【 表示 / 非表示

  • 1999年03月

    慶應義塾, 医学部

    大学, 卒業

  • 2006年03月

    慶應義塾, 医学研究科, 外科学

    大学院, 単位取得退学, 博士

学位 【 表示 / 非表示

  • 博士(医学), 慶應義塾, 課程, 2010年03月

 

著書 【 表示 / 非表示

  • ハートナーシング

    岡本一真, 饗庭了, 四津良平., 2005年

    担当範囲: 761-5

論文 【 表示 / 非表示

  • Kinked Graft and Anastomotic Stenosis-induced Hemolytic Anemia Requiring Reoperation

    Kitahara, H., Yoshitake, A., Hachiya, T., Okamoto, K., Kawaguchi, S. and Shimizu, H.

    Ann Vasc Surg 2015年10月

    ISSN  1615-5947

     概要を見る

    We report a case of hemolytic anemia caused initially by narrowing of a proximal anastomotic site and subsequently by a kinked prosthetic graft following total aortic arch replacement. A 55-year-old man was diagnosed with acute type A aortic dissection by computed tomography. After total aortic arch replacement, hemolytic anemia and renal dysfunction developed. Computed tomography detected narrowing of proximal anastomotic site of the graft. Removing the graft and ascending aortic replacement resolved the signs of hemolytic anemia. However, fifty days after the surgery, severe hemolytic anemia developed again. Computed tomography revealed a sharply kinked graft. Total arch replacement was again performed to resect the kinked graft. He was discharged on the 24th postoperative day without hemodialysis.

  • Successful management of severe unilateral re-expansion pulmonary edema after mitral valve repair with mini-thoracotomy using extracorporeal membrane oxygenation

    Kitahara, H., Okamoto, K., Kudo, M., Yoshitake, A., Hayashi, K., Inaba, Y., Ai, K., Suzuki, T., Morisaki, H. and Shimizu, H.

    Gen Thorac Cardiovasc Surg 2015年09月

    ISSN  1863-6713

     概要を見る

    A 60-year-old man received mitral valve repair via right mini-thoracotomy, which was followed by unilateral re-expansion pulmonary edema on the right side and severe hemoptysis just after the surgery. Despite differential lung ventilation with unilateral high positive end expiratory pressure was initiated for the affected right lung, respiratory function did not improved and hemodynamics was collapsed in the next day. Veno-venous extracorporeal membrane oxygenation was initiated by cannulation of the right jugular and the left femoral vein. After pulmonary function recovered gradually, veno-venous extracorporeal membrane oxygenation was terminated on the fifth postoperative day. He was discharged in ambulatory condition on postoperative day 52.

  • Designing innovative retractors and devices to facilitate mitral valve repair surgery

    Okamoto, K. and Yozu, R.

    Ann Cardiothorac Surg 4 ( 4 ) 364 - 9 2015年07月

    ISSN  2225-319X

     概要を見る

    Various devices have been developed to facilitate mitral valve surgery, including those that improve mitral valve exposure and assist surgeons with associated procedures. Choosing appropriate supporting devices when performing minimally invasive mitral valve surgery (MIMVS) through a minithoracotomy with endoscopic assistance is critical. Depending on the surgeon's preference, trans-thoracic or trans-working-port left atrial retractors can be utilized. Although the trans-thoracic retractors provide a simple and orderly working space around the minithoracotomy working port, the positioning of the shaft is difficult and there is an implicit risk of chest wall bleeding. On the other hand, the trans-working-port type provides excellent exposure, is easily handled and manipulated, and facilitates surgeries involving various anatomical structures without special training. A great deal of understanding and knowledge about retractors is necessary to achieve the optimal exposure required to facilitate surgical techniques, and to maintain a reproducible and safe surgical system during mitral valve surgery.

  • Cerebral Protection During Mitral Valve Repair in a Patient With Moyamoya Syndrome

    Okamoto, K., Arai, S., Hirabayashi, N., Morita, M., Kudo, M., Yozu, R. and Shimizu, H.

    Ann Thorac Surg 99 ( 6 ) 2208 - 10 2015年06月

    ISSN  1552-6259

     概要を見る

    In patients with moyamoya syndrome requiring heart surgery, the brain blood flow during the low perfusion state under cardiopulmonary bypass is a concern. We report on a successful mitral valve repair and tricuspid repair in a patient with moyamoya syndrome, performed using an integrated cerebral protection strategy with cerebral oxygen saturation monitoring, intraaortic balloon pumping, and cardiopulmonary bypass perfusion at a relatively high pressure. An integrated approach with a thorough discussion among cardiac surgeons, anesthesiologists, and perfusionists was invaluable to protect brain perfusion in a patient with moyamoya syndrome.

  • タイ チェンマイ大学病院胸部外科

    岡本, 一真

    胸部外科 68 ( 4 ) 308 - 309 2015年03月

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研究発表 【 表示 / 非表示

  • 右肺動脈閉塞をきたした上行大動脈置換術後吻合部仮性瘤の一例

    山辺健太朗、志水秀行、高橋辰郎、小林美里、岡本 一真、伊藤 努、工藤樹彦、饗庭 了、四津良平

    第147回日本胸部外科学会 関東甲信越地方会 (東京) , 2008年09月, 口頭(一般)

  • Bentall術後グラフト感染・仮性瘤に対し、Homograftを用いて大動脈基部置換を行った 1 例

    根本 淳、志水秀行、古梶清和、工藤樹彦、伊藤 努、岡本一真、木村成卓、小林美里、高橋辰郎、山辺健太朗、申 範圭、四津良平

    第142回日本胸部外科学会 関東甲信越地方会 (東京) , 2007年06月, 口頭(一般)

  • 遠位弓部大動脈瘤に対する治療戦略 : 外科手術とステントグラフト内挿術の短中期成績の比較

    木村成卓、 志水秀行、工藤,樹彦、岡本 一真、武田尚一郎、小林美里、宮木靖子、根本 淳、山辺健太朗、上田敏彦、橋本 統、栗林幸夫、井上寛治、四津良平

    第107回日本外科学会定期学術集会 (大阪) , 2007年04月, 口頭(一般)

    00406633936220080807015146PDF1.pdf

  • 脊髄保護の観点からみた下行および胸腹部大動脈瘤に対する治療成績

    岡本 一真、志水 秀行、上田 敏彦、根本 淳、山辺 健太朗、宮木 靖子、小林 美里、木村 成卓、武田 尚一郎、鈴木 亮、山崎 真敬、伊藤 努、工藤 樹彦、四津 良平

    第107回日本外科学会定期学術集会 (大阪) , 2007年04月, 口頭(一般)

    公開用PDF1

  • Human Mesenchymal Stem Cell from Human Chorionic Villi is a New Cell Source for Autologous Cardiac Stem Cell Therapy.

    Kazuma Okamoto, Naoko Hida, Shunichiro Miyoshi, Nobuhiro Nishiyama, Yukinori Ikegami, Daisuke Kami, Taro Uyama, Kenji Miyado, Kaoru Segawa, Hironori Asada, Yasunori Yoshimura, Ryo Aeba, Satoshi Ogawa, Akihiro Umezawa, Ryohei Yozu.

    Annual Scientific Session, American College of Cardiology (New Orleans) , 2007年03月, ポスター(一般)

     概要を見る

    Background: Marrow-derived mesenchymal stem cell (MSC) is a cell source for cardiac stem cell therapy, however, those cells may not function well because of patient’s disease background, age, and the ability of stem cell transdifferentiation that may be impaired. Placental chorionic villi are a good cell source for MSC since the young and fresh MSC can be obtained from them without any ethical problem. We hypothesized that placental chorionic villi cells (CVCs) can transdifferentiate into physiologically functioning cardiomyocyte in vitro. Methods and results: Human placental CVCs were isolated at male infant delivery, and confirmed them as infant-derived cells by sex chromosomal analysis (to exclude the contamination of maternal endometrial cells). Before cardiomyogenic induction, mRNA of Nkx-2.5, GATA-4, hBNP, and cardiac tropnonin-I (Trop-I) were detected by RT-PCR in the CVCs. The GFP-labeled CVCs were co-cultured with murine fetal cardiomyocyte to induce cardiomyogenic differentiation. A week after the induction, GFP-positive CVCs rhythmically and synchronously contracted, suggesting the presence of electrical communication between CVCs. The cardiomyocyte-specific action potential was obtained from spontaneous beating CVCs that showed the specific cardiac action potential plateau (duration; 209 +- 48 msec, amplitude 63.9 +- 8.4 mV, n=14). Immunocytochemical analysis with confocal laser microscopy revealed differentiated CVCs which were stained positive for anti-Trop-I, sarcomeric α-actinin (clearly stained striation pattern) and connexin 43 (diffused dot-like shapes at the margin of CVCs). The percentage of Trop-I positive cells in the GFP-positive cells was 14 +- 5%. The fractional shortening of the beating CVCs was 5.5 +- 0.4% (n=10). Conclusions: In CVCs, MSC with cardiomyogenic ability accounted for 14%. Although CVCs are usually considered as medical waste at delivery, we can obtain young stem cells from them without any ethical problem. We can utilize our own CVCs to repair our own heart disease in the future if they are stored at birth. CVCs are superior to marrow-derived MSC because they can be obtained from younger people and have a higher cardiomyogenic potential.

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担当経験のある授業科目 【 表示 / 非表示

  • 外科学(心臓血管外科)

    慶應義塾大学, 2018年度

  • 「先端医療技術」 人工心臓・人工血管

    慶應義塾, 2015年度

  • 臨床実習・臨床実習小講義 「心臓血管外科周術期管理」

    慶應義塾, 2015年度

  • 外科学

    慶應義塾, 2015年度